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What do these three treatments have in common?

All three are grouped as regenerative or skin-quality treatments. Rather than filling, freezing or lifting, they aim to support the skin's own repair processes so it looks healthier, smoother and more resilient over time. They are popular in Korea because they fit a philosophy of gradual, natural-looking improvement, which matches Re:berry's preference for stable change over short-lived effects.

The differences lie in what each product is made of, how it is delivered, and what it is most often used for.

What is Rejuran Healer?

Rejuran Healer is a branded polynucleotide (PN) injectable. PN consists of longer DNA chains purified from salmon. It is injected as many tiny deposits into the dermis, where it is thought to support fibroblasts, collagen production and hydration.

Feel: More viscous than PDRN, which may give a longer-lasting presence in the skin.
Common uses: Rough texture, enlarged pores, shallow acne scars, fine lines and thin skin.
Downtime: Small bumps typically last 1 to 3 days, with occasional bruising.
Course: Often 3 to 4 sessions about 2 to 4 weeks apart.

Re:berry also offers variants for specific areas; your doctor will advise which formulation fits.

What is PDRN?

PDRN stands for polydeoxyribonucleotide. It is also salmon-derived DNA, but in shorter fragments and typically in a thinner solution. PDRN has a long history in wound-healing medicine before being adopted in aesthetics.

Feel: Lighter and more fluid, spreading easily through the skin.
Common uses: Dehydration, sensitivity, redness after procedures, fine lines and general skin quality.
Downtime: Usually minimal, with small bumps for about a day or two.
Course: Commonly 3 to 4 sessions, sometimes more frequently in a short series.

For a shorter explanation of the PN versus PDRN difference, see what is the difference between Rejuran and PDRN?

What is exosome therapy?

Exosome therapy uses exosomes, tiny vesicles released by cells that carry proteins, lipids and genetic signals. Aesthetic exosome products are typically derived from cultured cells or plant sources. In Korea they are usually applied to the skin immediately after procedures that open microchannels, such as microneedling or fractional laser, so that the product can reach deeper layers.

Common uses: Calming and supporting skin after lasers, acne scar treatments, hair and scalp care, and general skin quality.
Downtime: Depends mainly on the procedure it is paired with.
Evidence: Exosome research is promising but still developing, and product regulation differs between countries. Ask the clinic what product is used and how it is applied.

How do they compare side by side?

By ingredient

Rejuran: longer polynucleotide chains. PDRN: shorter DNA fragments. Exosome: cell-derived vesicles, not DNA boosters.

By delivery

Rejuran and PDRN are injected into the skin. Exosome is most often applied topically after a procedure that allows penetration, though some products are injected.

By typical goal

Rejuran is often chosen for texture, scarring and resilience. PDRN is often chosen for hydration, calming and gentle maintenance. Exosome is often chosen to support recovery after more intensive procedures.

By comfort and downtime

Injected boosters involve many small needle points, so numbing cream is common and small bumps follow. Exosome application itself is gentle, but the procedure it accompanies sets the downtime.

Which one is right for me?

There is no single answer, and Re:berry's approach is to diagnose first. Some general patterns:

Acne scars and rough texture: Rejuran is common, sometimes with laser plus exosome. See Rejuran Healer for acne scars.
Dehydrated or sensitive skin: PDRN may be a gentle starting point.
After resurfacing or fractional laser: Exosome is often applied to support calming.
Fine lines and early aging: Rejuran or PDRN, often combined with energy-based lifting.

Many patients combine two of these. For example, a laser session with exosome applied afterward, followed by a course of Rejuran. The doctor sets the order and spacing.

Who should avoid these treatments?

Rejuran and PDRN are usually avoided with a fish or salmon allergy, during pregnancy and breastfeeding, and with active skin infection. Exosome products are generally avoided during pregnancy and with active infection, and suitability depends on the specific product. Tell the doctor about autoimmune conditions, blood thinners and recent procedures.

How should I plan this around a trip?

A full course of any of these treatments usually requires several visits, which can be difficult on a short stay. Visitors often start with one session and continue on their next trip, or combine one booster session with a laser and exosome. Share your travel dates at consultation so the plan fits your schedule.

What should I ask at consultation?

Ask which product is being used, how it is delivered, how many sessions are planned and what downtime to expect for your skin. It is also reasonable to ask how the doctor will judge progress between sessions.

Book a booster consultation in Hongdae

Pricing depends on the product, the area treated and the number of sessions, and it is confirmed in writing at consultation. Multilingual consultation support is available; please confirm languages when booking. Request an appointment through our Booking page.

Can I combine Rejuran and exosome in one visit?

Yes, this combination is common. For example, the doctor may perform a laser or microneedling, apply exosome, and inject Rejuran in the same visit or schedule them on separate days. Whether same-day combination suits you depends on your skin's sensitivity and the procedures involved.

Which booster has the least downtime?

PDRN typically has the lightest downtime among injected boosters, with small bumps settling in about a day. Exosome applied after a gentle procedure can also have minimal downtime, though this depends on the paired treatment. Rejuran may leave bumps for one to three days.

Are these treatments safe for sensitive skin?

Many patients with sensitive skin receive PDRN or Rejuran, and exosome is often used to calm skin after procedures. However, any injection can cause redness, swelling or bruising, and allergic reactions are possible. The doctor will review your history and may suggest a cautious first session.

How long do results last?

After a full course, improvements in skin quality often last several months. Maintenance sessions every three to six months are commonly suggested for boosters. Results depend on age, skin condition, lifestyle and sun protection, and they vary by individual. Your doctor can suggest a maintenance rhythm that fits your skin.