Rejuran and PDRN are both salmon-derived DNA skin boosters, but they differ in structure. Rejuran Healer uses polynucleotides (PN), which are longer DNA chains with a thicker texture, while PDRN uses shorter fragments in a lighter solution. At Re:berry Hongdae, the choice depends on your skin concern and sensitivity. Results vary by individual.
Re:berry Clinic Hongdae · Information reviewed for accuracy · Results vary by individual.
How are Rejuran and PDRN made?
Both products are made from DNA extracted and purified from salmon. The DNA is processed into fragments of different lengths. PDRN (polydeoxyribonucleotide) consists of shorter fragments and has a long history in wound-healing medicine. PN (polynucleotide), used in Rejuran Healer, consists of longer chains, which gives it a thicker, more viscous texture.
How do they differ in practice?
- Texture: Rejuran is thicker, so it may stay in the skin a little longer and provide more structural support. PDRN spreads more easily.
- Typical goals: Rejuran is often chosen for rough texture, enlarged pores, shallow acne scars and thin skin. PDRN is often chosen for dehydration, sensitivity, redness after procedures and gentle maintenance.
- Feel during treatment: Both involve many small injections, usually after numbing cream. Some patients find thicker PN products slightly more uncomfortable.
- Downtime: Both commonly leave small bumps that settle in about one to three days, with occasional bruising.
Which one should I choose?
There is no universal winner. The right choice depends on your concerns, skin sensitivity and schedule. Some patients alternate between the two or combine them with lasers and energy-based lifting. Re:berry's approach is to diagnose first, then design a combination that supports stable improvement. For a wider comparison that includes exosome therapy, see Rejuran vs PDRN vs exosome.
Who should avoid both?
People with a fish or salmon allergy, those who are pregnant or breastfeeding, and anyone with active skin infection in the area are usually advised to avoid these boosters. Tell the doctor about blood thinners and autoimmune conditions. Pricing depends on the product and number of sessions and is confirmed in writing at consultation.
How many sessions do they need?
Both are usually given as a course of about three to four sessions spaced two to four weeks apart, followed by maintenance every few months. Exact timing depends on your skin and goals.
At a glance
- Source: Both purified from salmon DNA
- Rejuran: Polynucleotide (PN), longer chains, thicker gel
- PDRN: Polydeoxyribonucleotide, shorter fragments, thinner fluid
- Common uses: Rejuran for texture and scars; PDRN for hydration and calming
- Downtime: Small bumps for about 1 to 3 days with either
Related questions
Is Rejuran a type of PDRN?
Rejuran is often described alongside PDRN because both are salmon-derived DNA boosters. Technically, Rejuran Healer is a polynucleotide (PN) product with longer DNA chains, while PDRN refers to shorter fragments. They are related but not identical, which is why they may be chosen for different goals.
Which lasts longer, Rejuran or PDRN?
Because PN is thicker, Rejuran is often thought to remain in the skin a little longer, but overall skin improvements from either product typically last several months after a full course. Maintenance timing depends on your skin, age and lifestyle, and results vary by individual.
Can Rejuran and PDRN be used together?
Some doctors combine or alternate PN and PDRN products, for example using PDRN for broad hydration and Rejuran for scarred or textured areas. Whether this suits you depends on your diagnosis and how your skin responds. Discuss options at consultation so the plan matches your goals.
Keep reading
Before you book
This page is general information, not a diagnosis. Suitability, dose, number of sessions and expected results are decided by a doctor at consultation, and results vary by individual. Possible side effects include redness, swelling and bruising. Pricing is confirmed in writing before any treatment. See our medical disclaimer.
Still have a question?
A doctor at Re:berry Clinic Hongdae can answer it for your skin specifically. Multilingual consultation support is available.