Guide

What is PDRN?

PDRN stands for polydeoxyribonucleotide, a mixture of short DNA fragments typically derived from salmon. In medicine it has been studied for wound healing and tissue repair. In aesthetics it is injected into the dermis as a skin booster, where it is thought to support fibroblast activity, collagen production, hydration and a calmer, healthier skin environment.

PDRN is closely related to polynucleotide (PN) products such as Rejuran. The main differences lie in fragment length, concentration and texture, which can affect how a product feels in the skin and how long it lingers. See what is the difference between Rejuran and PDRN? for a short explanation.

Why use PDRN for fine lines?

Not all lines are the same. Fine lines are shallow and often come from dehydration, thinning skin and early collagen loss, while deeper wrinkles and folds involve muscle movement or volume loss. Because PDRN works on skin quality, it tends to suit the first group.

Crepey lines under the eyes and on the cheeks
Dehydration lines that appear when the skin is pushed
Fine texture lines on the forehead or around the mouth that are present at rest
Neck lines with thin, tired-looking skin

For lines caused mainly by expression, such as crow's feet when smiling or frown lines, Botox is usually more direct. Deep nasolabial folds typically respond better to filler or lifting.

Who is a good candidate?

PDRN typically suits adults in their late 20s onward who want a natural improvement in texture and glow with short recovery. It is often chosen by people with sensitive skin or those recovering from lasers. It is usually avoided during pregnancy and breastfeeding, with active infections in the area, or with a fish allergy. Tell the doctor about blood thinners, supplements that increase bruising and any autoimmune conditions.

What to expect at your appointment

Consultation: The doctor examines your lines at rest and in motion to see which are suitable for a booster.
Numbing: Numbing cream is applied for about 30 minutes.
Injection: Small amounts are placed across the treatment area by hand or with an injector device.
Finish: The skin is cleaned and calmed, and you can usually return to normal plans.

Downtime and side effects

Small raised bumps typically settle within a day or two. Redness, mild swelling and occasional bruising can occur, especially around the eyes. Avoid makeup for the rest of the day, and skip saunas, alcohol and intense exercise for a day or two. See aftercare after skin boosters.

How many sessions are needed?

A common plan is 3 to 4 sessions about 2 to 4 weeks apart, with improvement building over 4 to 8 weeks. Many patients then consider maintenance every few months. Results vary by individual, and PDRN does not stop new lines from forming.

What pairs well with PDRN?

Skin Botox: Very diluted botulinum toxin placed superficially may refine texture and pores alongside PDRN.
Energy-based lifting: Devices such as Sofwave or Thermage FLX stimulate collagen at different depths, while PDRN supports skin quality.
HydraFacial: A gentle surface treatment that can be added for immediate glow.

Re:berry designs combinations based on diagnosis, so the order and spacing will be confirmed at consultation.

How should I prepare for a PDRN session?

For about a week beforehand, avoid supplements and medications that can increase bruising, such as aspirin, fish oil, ginkgo or high-dose vitamin E, unless a doctor has prescribed them. Pause strong exfoliants or retinoids for a few days if your skin is sensitive. Plan the session at least two to three days before photos or events, particularly if the under-eye area is being treated, so any small bruises have time to fade.

How will I know if PDRN is working?

Most patients notice changes in how their skin feels before they see changes in lines. Skin often feels more supple, makeup sits more smoothly, and dehydration lines look softer after the second or third session. Photos taken under the same lighting at the start and end of a course are the most reliable way to judge progress.

What are the alternatives?

Alternatives include Rejuran Healer for a thicker PN booster, Botox for fine lines caused by expression, and collagen-focused boosters such as Laetigen. Each has a different feel, downtime and session plan. Compare skin boosters in Rejuran vs PDRN vs exosome.

Pricing depends on the product, area and number of sessions, and it is confirmed in writing at consultation. Request an appointment on our Booking page.

Is PDRN the same as salmon DNA injection?

Most PDRN products used in aesthetics are derived from salmon DNA, which is why the treatment is often nicknamed salmon injection. The DNA is highly purified and fragmented. Anyone with a fish allergy should mention it, as the doctor may recommend a different booster.

Can PDRN be used under the eyes?

PDRN is commonly used to improve crepey, thin skin around the eyes. Because the area is delicate, there may be a higher chance of bruising or swelling, so plan a day or two without important events. Hollows caused by volume loss may need a different treatment.

How long do PDRN results last?

After a full course, many patients find the improvement in texture and glow lasts several months. Longevity depends on age, skin condition, sun exposure and lifestyle. Maintenance sessions are often considered every three to six months. Results vary by individual.