Re2O is an injectable skin booster made from human acellular dermal matrix, a purified human-derived material containing type I and type III collagen. It is designed to replenish dermal structure directly rather than only signaling skin to repair. At Re:berry Hongdae it is used for thinning skin, dehydration and texture, usually in about three sessions. Results vary by individual.
Re:berry Clinic Hongdae · Information reviewed for accuracy · Results vary by individual.
How does Re2O work?
Re2O belongs to a newer group of boosters that supply structural material to the skin. Its main component is a human acellular dermal matrix: skin tissue processed to remove cells, leaving a purified collagen-rich framework. When injected in small amounts into the dermis, this material is intended to replenish the extracellular matrix and act as a scaffold for your own cells.
This differs from boosters that mainly attract water, such as hyaluronic acid, or those that mainly send repair signals, such as PDRN or polynucleotides. For more detail, visit our Re2O rejuvenation booster page.
What can Re2O help with?
- thin or crepey skin that lacks density;
- dehydrated skin that looks flat or dull;
- fine lines and loss of bounce;
- rough texture and shallow irregularities;
- skin quality support alongside lifting treatments.
It is not a volumizing filler and does not lift sagging tissue on its own.
What is a typical treatment plan?
Many plans involve three sessions about four weeks apart, followed by maintenance every several months if desired. Each session usually includes numbing cream and around 15–30 minutes of injections. Improvements tend to develop gradually over weeks as the skin integrates the material.
Who may Re2O suit?
Re2O is often discussed with people whose skin feels thin, dry or less resilient, including those who have tried hydrating boosters and want a structure-focused option. It may also be considered as part of a wider plan after lifting treatments or lasers, where improving skin quality helps results look more natural. The doctor decides whether Re2O fits after examining your skin.
Can Re2O be combined with other treatments?
Yes. Following Re:berry's approach of designing combinations, Re2O may be paired with lasers for tone, HydraFacial for surface hydration, or lifting devices such as Thermage FLX. Spacing between treatments is planned at consultation.
Are there side effects?
Temporary small bumps, redness, mild swelling and pinpoint bruising at injection points are common and usually settle within one to three days. Rare risks include infection, prolonged lumps or allergic reaction. Pregnancy, active skin infection and certain medical conditions may be reasons to postpone. Because Re2O is human-derived, ask the doctor about its sourcing and processing at consultation. Results vary by individual.
To compare options, see Laetigen vs Re2O and our Re2O for dehydrated skin guide.
At a glance
- Main ingredient: Human acellular dermal matrix (collagen types I and III)
- Works by: Replenishing extracellular matrix and acting as a scaffold
- Sessions: Often 3 sessions about 4 weeks apart
- Downtime: Small bumps, redness or swelling for 1–3 days
- Best for: Thin, dehydrated or crepey skin and texture
Related questions
How is Re2O different from Rejuran?
Rejuran Healer is a polynucleotide booster derived from salmon DNA and is mainly used to support skin recovery and barrier health. Re2O is a human-derived collagen matrix designed to replenish dermal structure. They work differently, and the doctor may suggest one, the other or a combination depending on your skin concerns.
Can I wear makeup after Re2O?
Many clinics suggest avoiding makeup on the treated area for the rest of the day so injection points can close. From the next day, gentle makeup is usually fine. If small bumps are still visible, a light concealer can help. Follow the specific aftercare instructions you receive at Re:berry Hongdae.
How long do Re2O results last?
After a course of sessions, effects are often described as lasting around six months to a year, but this varies with age, skin condition, sun exposure and lifestyle. Many patients choose maintenance sessions. The doctor will suggest an interval that suits your skin and goals.
Keep reading
Before you book
This page is general information, not a diagnosis. Suitability, dose, number of sessions and expected results are decided by a doctor at consultation, and results vary by individual. Possible side effects include redness, swelling and bruising. Pricing is confirmed in writing before any treatment. See our medical disclaimer.
Still have a question?
A doctor at Re:berry Clinic Hongdae can answer it for your skin specifically. Multilingual consultation support is available.